Genetic determinants of hepatitis B vaccine response
نویسندگان
چکیده
Hepatitis B is a major public health problem. Approximately one-third of the world’s population has serological evidence of infection with hepatitis B virus (HBV). 350 million of these are carriers who have chronic HBV infection, and about a million of these carriers die each year from chronic liver disease, including cirrhosis and liver cancer. Fortunately, HBV is a vaccine preventable disease, and the increasing adoption of this vaccine has led to dramatic reductions in the morbidity and mortality caused by this virus. However, as much as 10% of the population fails to mount a protective immune response after vaccination. Twin and other epidemiological studies have demonstrated an unusually high heritability to this trait, which suggests a high likelihood of identifying genetic variation influencing HBV vaccine response. In search of such variation, we performed a two stage Genome Wide Association Scan (GWAS) in participants of a vaccine efficacy trial from Batam, Indonesia. In Stage 1, we used the fixed content Illumina Infinium 550K SNP BeadChip to genotype 2000 vaccinees. Tests of association were performed to identify 7,000 SNPs to carry forward to a second stage of 2,300 vaccinees. Several independent regions attained genome-wide significance, including the HLA-DR and HLADP regions. Additional details on the study design and results will be discussed in the presentation.
منابع مشابه
The factors influencing the immune response to hepatitis B vaccine and persistence of the protection.
Hepatitis B virus (HBV) infection and its sequelae which include cirrhosis and hepatocellular carcinoma is a major public health problem throught the world.The WHO strategy for effective control of HBV infection is vaccination with the surface antigen of virus(HBsAg).The results obtained from a large number of studies demonstrated that the vaccine induces a protective antibody resonse (anti-HB...
متن کاملcan Isolated hepatitis B core antibody in HIV-infected patients response to hepatitis B vaccine help to elucidate the cause?
متن کامل
Unresponsiveness to Recombinant Hepatitis B Vaccine in Healthy Iranian Neonates: Association with HLA Antigens
Background: Hepatitis B is an important infectious disease. Since several years ago, mass vaccination against this viral infection has become as part of routine vaccination schedule of Iran. However, some healthy neonates, children and adults fail to generate a protective antibody response after vaccination.Objectives: To investigate distribution of HLA class-I and class-II antigens in health...
متن کاملStudy of Immune Response in Infants of Non-Gestational Diabetic Mothers
Background Infants of diabetic mothers (IDMs) have significantly greater risk for spontaneous abortion, stillbirth, congenital malformations and perinatal mortality and morbidity but whether maternal DM affects the neonatal innate immune system is unknown. We aimed to assess the immune response of infants of diabetic mothers (IDMs) with non-gestational DM for Hepatitis B vaccine and to compare ...
متن کاملEffect of selenium on immune response against hepatitis B vaccine with accelerated method in insulin-dependent diabetes mellitus patients
Background: Poor response to various vaccines especially hepatitis B is common. The purpose of this study was to evaluate the effect of selenium on immune response against hepatitis B vaccine with accelerated method in insulin-dependent diabetes mellitus patients.Methods: In this randomized clinical trial study, 62 insulin dependent diabetic patients were divided into case and control groups (e...
متن کاملAnti-HBs Response and its Protective Effect in Children and Adults Receiving Hepatitis B Recombinant Vaccine in Tehran
Background: Following WHO recommendation, HBV vaccination has been integrated into EPI program in Iran since 1996. Objective: To evaluate the immunogenicity and protective effect of HB vaccine (recombinant Heberbiovac ,Cuba ) in vaccinated children and adults . Methods: A total of 542 cases (340 children and 202 adults) were vaccinated using a three-doses schedule of zero, one and six month. ...
متن کامل